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The effect of an isoprenaline infusion on the splenic blood flow and intrasplenic platelet kinetics
Author(s) -
Wadenvik Hans,
Kutti Jack
Publication year - 1987
Publication title -
european journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0902-4441
DOI - 10.1111/j.1600-0609.1987.tb00155.x
Subject(s) - platelet , isoprenaline , blood flow , mean platelet volume , medicine , spleen , blood volume , chemistry , anesthesia , endocrinology , stimulation
The effect of a constant isoprenaline infusion on the venous platelet count, splenic blood flow and intrasplenic platelet kinetics was investigated in 6 healthy male volunteers. The study was carried out using autologous 111 In‐labelled platelets and dynamic gamma camera imaging of the initial distribution of radiolabelled platelets between blood and splenic platelet pool. The isoprenaline infusions were administered i.v. over 30 min in a dose of 0.03 μg/kg/min. These infusions significantly increased the splenic blood flow and the size of the exchangeable splenic platelet pool. Concomitantly, there was a decrease of labelled as well as unlabelled platelets in the peripheral blood. The intrasplenic platelet transit time was not affected. Before start of infusion, the splenic blood flow was 6.1 ± 2.9 (SD) % of total blood volume/min and the splenic platelet pool size 34 ± 9 (SD) %. During infusion the corresponding values were 8.7 ± 3.9 (SD) and 41 ± 11 (SD), respectively. It is concluded that an i.v. infusion of isoprenaline enhances splenic pooling of platelets as a result of an increase in splenic blood flow.