Premium
Effect of D‐penicillamine on human granulopoiesis in vitro
Author(s) -
Aymard J. P.,
Herbeuval M.,
Netter P.,
Legras B.,
Streiff F.,
Herbeuval R.
Publication year - 1985
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1985.tb02780.x
Subject(s) - granulopoiesis , penicillamine , granulocyte , in vitro , bone marrow , chemistry , monocyte , human bone , immunology , medicine , pharmacology , biology , biochemistry , haematopoiesis , microbiology and biotechnology , stem cell
The effect of D‐penicillamine on human bone marrow granulocyte‐monocyte precursor cells (CFU‐C) is studied in vitro. Bone marrow samples were obtained from 47 donors (40 patients and 7 healthy volunteers) and cultured in semisolid agar in the presence of various concentrations of the drug. We found an inhibitory, possibly dose‐dependent, effect of D‐penicillamine on colony formation. The pathophysiological mechanism and the clinical relevance of this effect remain poorly understood. These findings, however, emphasize the need for careful monitoring of the granulocyte counts during D‐penicillamine therapy.