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Long Term Therapy of Pernicious Anaemia with the Depot Cobalamin Preparation Betolvex®
Author(s) -
BastrupMadsen Poul,
HellebergRasmussen I.,
Nørregaard Svend,
Halver Bent,
Hansen Tage
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb02137.x
Subject(s) - cobalamin , pernicious anaemia , pernicious anemia , medicine , term (time) , depot , intrinsic factor , vitamin b12 , anemia , history , physics , archaeology , quantum mechanics
The value of a depot cobalamin preparation Betolvex® (cyanocobalamin‐tannin complex suspended in a sesame‐oil aluminium‐monostearate gel) in the maintenance therapy of pernicious anaemia was investigated in 120 patients followed up for between 8 and 15 years. Complete haematological remission was maintained in all patients, and none developed B 12 neuropathy after the start of treatment. No side‐effects were observed. The mean values of S‐cobalamin were above the reference limits when 1 mg cobalamin was given every 2 months, and high within the reference limits when given at 3 monthly intervals. The cobalamin content in the liver tissue in 2 patients who had received 1 mg cobalamin every 3 months for 6 years revealed normal values. Thus, 1 mg of the depot cobalamin preparation given at intervals of 3 months should provide adequate maintenance therapy in pernicious anaemia.