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Immunoglobulin Synthesis in Hairy Cell Leukaemia
Author(s) -
Reynes M.,
Tricottet V.,
Capron F.,
Diebold J.
Publication year - 1983
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1983.tb01552.x
Subject(s) - endoplasmic reticulum , hairy cell , antibody , cell , surface immunoglobulin , microbiology and biotechnology , ultrastructure , biology , hairy cell leukemia , chemistry , pathology , b cell , immunology , medicine , leukemia , anatomy , biochemistry
3 cases of hairy cell leukaemia were studied with ultrastructural immunocytochemical methods using an anti human Ig HRPO‐Fab fragment. Ig were detected on the cell surface, in the perinuclear cisterna and endoplasmic reticulum of hairy cells. Evidence of Ig in these sites demonstrates a B‐lymphoid differentiation of the leukaemic cells.