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Cell Cycle Distribution of Erythroblasts in P. falciparum Malaria
Author(s) -
Wickramasinghe S. N.,
Abdalla S.,
Weatherall D. J.
Publication year - 1982
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1982.tb00567.x
Subject(s) - malaria , feulgen stain , plasmodium falciparum , thymidine , cell cycle , biology , immunology , cell , genetics , in vitro , staining
The cell cycle distribution of the erythroblasts of 6 Gambian children with P. falciparum malaria was determined using the technique of combined Feulgen microspectrophotometry and 3 H‐thymidine autoradiography. The data showed evidence of a perturbation of erythro‐blast kinetics in all 6 children. The abnormalities were more marked in the children with chronic malaria than in those with acute malaria and predominantly affected the early polychromatic erythroblasts. The disturbances observed in chronic malaria included an increased proportion of cells in the G 2 phase and an arrest during the progress of some cells through the S phase. The latter defect was not seen in the children with acute malaria.