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Prognosis in Acquired Aplastic Anaemia A Multivariate Statistical Analysis of 80 Cases
Author(s) -
Rozman Ciril,
Marin Pedro,
Granena Albert,
Nomdedeu Benet,
Montserrat Emili,
Feliu Evarist,
Liuis Joan,
Corrons Vives
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01668.x
Subject(s) - univariate , logistic regression , univariate analysis , medicine , bone marrow transplantation , multivariate analysis , multivariate statistics , statistical analysis , bone marrow , oncology , statistics , mathematics
Prognostic factors were studied in a series of 80 patients with aplastic anaemia. The most important and easily obtainable individual variables, isolated in a previous univariate statistical analysis, were placed in a linear logistic regression model. A prognostic formula was derived containing the following 4 variables, in decreasing order of significance: (1) reticulocytes, (2) interval from onset of symptoms to first visit, (3) mean red cell volume, and (4) platelets. The prognostic formula permits an estimate of the probability of death within 3 months from the first visit. Its usefulness in several clinical situations, especially those related to bone marrow transplantation, is illustrated.