Tγ Cell Deficiency in Idiopathic Thrombocytopenic Purpura (ITP) | Zendy

Lauria F. | Zendy; Mantovani V. | Zendy; Catovsky D. | Zendy; Guarini A. | Zendy; Gobbi M. | Zendy; Gugliotta L. | Zendy; Mirone E. | Zendy; Tura S. | Zendy

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Tγ Cell Deficiency in Idiopathic Thrombocytopenic Purpura (ITP)

Author(s) -

Lauria F.,

Mantovani V.,

Catovsky D.,

Guarini A.,

Gobbi M.,

Gugliotta L.,

Mirone E.,

Tura S.

Publication year - 1981

Publication title -

scandinavian journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.904

H-Index - 84

eISSN - 1600-0609

pISSN - 0036-553X

DOI - 10.1111/j.1600-0609.1981.tb01640.x

Subject(s) - splenectomy , thrombocytopenic purpura , medicine , immunology , pathogenesis , spleen , purpura (gastropod) , abnormality , immune system , biology , ecology , psychiatry

A significant reduction in the proportion and absolute number of circulating T γ (suppressor) lymphocytes was observed in 15 adult patients with idiopathic thrombocytopenic purpura (ITP). The proportion of T γ cells was also reduced in the spleen of four patients so investigated. This abnormality was not seen in 5 patients cured by splenectomy whilst it persisted in 3 who remained thrombocytopenic after splenectomy. The proportion of Tμ (helper) lymphocytes in ITP was normal. These findings, similar to those reported in systemic lupus erythematosus, suggest that an inbalance of the immunoregulatory T‐cell subsets may be important in the pathogenesis of ITP.

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