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Chromosomal Abnormalities in Acute Promyelocytic Leukaemia
Author(s) -
Chapelle Albert de la,
Knuutila Sakari,
Elonen Erkki,
Vuopio Pekka
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01624.x
Subject(s) - isochromosome , chromosomal translocation , chromosome , mitosis , long arm , karyotype , bone marrow , biology , medicine , genetics , pathology , gene
In 2 patients with acute promyelocytic leukaemia (APL) an isochromosome for the long arm of chromosome 17 was seen in part of the bone marrow mitoses at diagnosis and relapse, respectively. In one of them, there was a t(15q+;17q‐) affecting one of the No. 15 chromosomes and both arms of the isochromosome. Thus the translocation must have occurred before (or simultaneously with) the formation of the isochromosome. This is the first example of t(15;17) out of 17 patients with APL studied in Finland