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Erythrocytotoxicity Induced by Cancer Chemotherapeutic Agents
Author(s) -
Barr Ronald D.,
Davidson Alan R.,
Jung Lawrence K. L.,
Pai K. R. Mohan
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb01415.x
Subject(s) - medicine , cancer , in vitro , erythrocyte fragility , immunology , cancer research , pharmacology , oncology , biology , hemolysis , biochemistry
Increased osmotic fragility and methaemoglobin generation in vitro have resulted from the exposure of normal human erythrocytes to numerous cancer chemotherapeutic agents. These findings offer a possible explanation for the earlier, consistent clinical observation of the rapid development of anaemia, during consolidation therapy, in children with acute lymphoblastic leukaemia in remission.