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High Prevalence of Increased Osmotic Fragility of Red Blood Cells among Norwegian Blood Donors
Author(s) -
Godal H. C.,
Heistø H.
Publication year - 1981
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1981.tb00448.x
Subject(s) - norwegian , erythrocyte fragility , fragility , medicine , immunology , chemistry , hemolysis , philosophy , linguistics
Increased osmotic fragility of red blood cells was found in 9 out of 1008 Norwegian blood donors. In addition, increased osmotic fragility was found in 3 out of 23 first grade relatives and in 1 out of 4 spouses of individuals with the same condition. Finally, there was a positive correlation between increased osmotic fragility and morphological signs of spherocytosis (P < 0.05). No definite conclusions with respect to underlying mechanism(s) for this high prevalence of non‐symptomatic increased osmotic fragility can be offered, but very mild hereditary spherocytosis, environmental factors and even a normal variant, never associated with haemolysis, may have contributed. Furthermore, until more specific and sensitive laboratory techniques have been introduced, a proper distinction between these 3 conditions cannot be made.