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Acute Myeloblastic Leukaemia in Sarcoidosis Treated with Methotrexate
Author(s) -
Hermann Christian,
Andersen Erik,
Videbæk Aage
Publication year - 1980
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1980.tb01331.x
Subject(s) - methotrexate , myeloid leukaemia , sarcoidosis , medicine , prednisone , chronic myeloid leukaemia , myeloid , gastroenterology
A 60‐year‐old man with sarcoidosis of skin and knee joints was treated with prednisone and methotrexate (MTX). A total of 590 mg MTX was given over two periods each of 3 months duration. 4 1/2 years after the first MTX dose he developed acute myeloid leukaemia. Only one more case of acute myeloid leukaemia following MTX treatment for a benign disease has been described, and until further cases have been reported the correlation might be considered a matter of simple coincidence.