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Effect of Tissue Specific Mitotic Inhibitors on Survival Time of Spontaneous and Virus‐Induced Murine Leukaemia and Influence on Myocardial Degeneration
Author(s) -
Ebbesen P.,
Olsson L.
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb02503.x
Subject(s) - spleen , mitosis , degeneration (medical) , biology , virus , neoplasm , immunology , pathology , andrology , virology , medicine , microbiology and biotechnology
Treatment of adult AKR mice with tissue‐specific mitotic inhibitor mol. wt. 1,000–20,000 extracted from the AKR thymus significantly delayed the onset of spontaneous thymus leukaemia, whereas extracts of other organs were without effect. A slight prolongation of survival time was found with spleen extract when administered to BALB/c mice infected with Rauscher virus, which causes leukaemia starting in the spleen. Thymus extracts of MW 100,000–300,000 caused myocardial degeneration in some leukaemic and nonleukaemic mice.