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Surface Membrane Characteristics of Cells from Human Acute Monocytic Leukaemia
Author(s) -
Parker A. C.,
Dewar A. E.,
Wilson C. D.,
Young S.,
Stuart A. E.
Publication year - 1978
Publication title -
scandinavian journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.904
H-Index - 84
eISSN - 1600-0609
pISSN - 0036-553X
DOI - 10.1111/j.1600-0609.1978.tb02484.x
Subject(s) - membrane , thp1 cell line , microbiology and biotechnology , chemistry , biology , cell culture , biochemistry , genetics
The clinical and laboratory features of 4 patients with acute monocytic leukaemia are described. Surface membrane receptor studies of these patients have shown increasing strength of receptor expression occurs with increasing morphological maturity of the monocyte. In addition, the study shows that expression of membrane receptors can vary from patient to patient and also with time and treatment in an individual patient. A further finding has been the loss of positivity with specific anti‐monocytc serum when the disease becomes refractory to therapy.