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Basal cell carcinoma with myoepithelial differentiation: a distinct plasmacytoid cell variant with hyaline inclusions
Author(s) -
Na So Young,
Choi YouDuk,
Choi Chan,
Kim SeongJin,
Won Young Ho,
Yun Sook Jung
Publication year - 2011
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.2010.01579.x
Subject(s) - hyaline , pathology , myoepithelial cell , biology , basal cell , basal cell carcinoma , carcinoma , basal (medicine) , myoepithelioma , cell of origin , cell , medicine , immunohistochemistry , endocrinology , genetics , insulin
We describe a 74‐year‐old man presenting with a 10‐year history of an asymptomatic, skin‐colored hard plaque on his left cheek. Microscopy revealed well‐demarcated tumor with peripheral palisading and peritumoral clefting in the dermis. The tumor included many plasmacytoid cells with cytoplasmic hyaline inclusions and eccentric nuclei. Electron microscopic examination showed that hyaline inclusions consisted of aggregates of filaments. Immunoperoxidase staining showed diffuse cytoplasmic expression of 34bE12, smooth muscle actin, calponin and p63. We diagnosed the patient with basal cell carcinoma (BCC) with myoepithelial differentiation and treated him with excision. Eight months postoperatively, the patient remained well with no recurrence. This distinct variant of BCC with myoepithelial differentiation, showing cytoplasmic hyaline inclusions and eccentric nuclei, has previously been confusingly termed ‘signet‐ring cell BCC’. However, these plasmacytoid cells differ from signet‐ring cells with vacuolated cytoplasm. To avoid confusion, we suggest the designation ‘BCC with myoepithelial differentiation’. Na SY, Choi Y‐D, Choi C, Kim S‐J, Won YH, Yun SJ. Basal cell carcinoma with myoepithelial differentiation: a distinct plasmacytoid cell variant with hyaline inclusions.