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Stewart‐Treves syndrome: an histogenetic (ultrastructural and immunohistological) study
Author(s) -
Kanitakis J.,
Bendelac A.,
Marchand C.,
RigotMuller G.,
Thivolet J.
Publication year - 1986
Publication title -
journal of cutaneous pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.597
H-Index - 75
eISSN - 1600-0560
pISSN - 0303-6987
DOI - 10.1111/j.1600-0560.1986.tb00458.x
Subject(s) - histogenesis , vimentin , pathology , keratin , biology , agglutinin , immunohistochemistry , intermediate filament , antigen , lectin , microbiology and biotechnology , medicine , immunology , cytoskeleton , cell , genetics
One case of the so‐called „Stewart‐Treves syndrome” (STS), appearing on a lymphoedomatous arm complicating radical mastectomy for brest cancer, was characterized electronmicroscopically and immunohistologically, in order to elucidate its disputed (epithelial vs endothelial) histogenesis. Epithelial and endothelial differentiation markers used comprised: antibodies against keratin, vimentin, factor VIII‐related antigen (F VIII‐RA), HLA‐DR antigens and the lectin Ulex europeaus agglutinin 1 (UEA I). At the ultrastructural level, neoplastic cells were found to contain typical Weibel‐Palade bodies, whereas by immunohistological techniques they proved to be keratin −negative/vimentin+, F VIII‐RA +, UEAI+, HLA‐DR+. These results rule out a possible epithelial differentiation and strongly favour an endothelial one for STS.
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