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The effect of topical cyclosporin A on the elicitation phase of allergic contact dermatitis
Author(s) -
Cole Gary W.,
Shimomaye Susan,
Goodman Matthew
Publication year - 1988
Publication title -
contact dermatitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.524
H-Index - 96
eISSN - 1600-0536
pISSN - 0105-1873
DOI - 10.1111/j.1600-0536.1988.tb05510.x
Subject(s) - allergic contact dermatitis , contact dermatitis , medicine , dermatology , allergen , patch test , allergy , penetration (warfare) , immunology , operations research , engineering
The effect of cyclosporin A (CSA) on the elicitation phase of allergic contact dermatitis was investigated. Initially, the ability of CSA to penetrate normal human cadaver skin was determined using 3 different vehicles. 10% CSA in Labrafil was found to be the must effective combination at achieving skin penetration (0.33%). Patients with known contact sensitivities to a variety of allergens were selected. After a 48‐h pretreatment with 10% CSA in Labrafil, skin sites were exposed to the appropriate contact allergen. 72 h later, the development of an eczemutous patch test reaction was evaluated. Only 1 of 10 patients showed unequivocal signs of suppression of allergic contact dermatitis