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Effects of experimental gingivitis on crevicular PGE 2 in a split mouth trial
Author(s) -
Deinzer Renate,
Waschul Bernd,
Herforth Armin
Publication year - 2004
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/j.1600-051x.2004.00506.x
Subject(s) - gingivitis , oral hygiene , dentistry , medicine , context (archaeology) , prostaglandin e , biology , paleontology
Abstract Objective: The study aimed to analyse the effects of experimental gingivitis on crevicular prostaglandin E 2 (PGE 2 ). An increase of PGE 2 was expected. Methods: Fourteen medical students refrained for 28 days from any oral hygiene procedures in two antagonistic quadrants while they maintained close to perfect oral hygiene in the remaining quadrants. Crevicular fluid samples were taken at baseline and at days 7, 14, 21 and 28 of experimental gingivitis both from quadrants with and without oral hygiene. PGE 2 ‐concentrations (ng/ml) and absolute levels (pg/sample) were analysed for quadrants with and without oral hygiene. Results: Comparison of quadrants with and without oral hygiene by repeated measures anova revealed no effects of experimental gingivitis both on crevicular PGE 2 ‐concentrations and absolute levels. Conclusion: The study does not support the notion that experimental gingivitis induces an increase of crevicular PGE 2 . The data are discussed in the context of other studies on PGE 2 concentrations in gingivitis. Close inspection of these studies reveals no clear evidence for an increase of local PGE 2 in gingivitis.