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Clonidine in the treatment of mixed bipolar disorder
Author(s) -
Kontaxakis V.,
Markianos M.,
Markidis M.,
Stefanis C.
Publication year - 1989
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1989.tb09242.x
Subject(s) - clonidine , dopamine , prolactin , medicine , endocrinology , psychopathology , bipolar disorder , psychology , serotonin , psychiatry , hormone , lithium (medication) , receptor
ABSTRACT In a mixed bipolar disorder patient, DST‐positive, treated with neuroleptics and antidepressants, the addition of clonidine (up to 0.6 mg/day) caused a rapid improvement in his psychopathology, without any significant side effects. The concentrations of the metabolites of noradrenaline, dopamine, and serotonin (MHPG, HVA, and 5‐HIAA), the hormone prolactin and the activity of dopamine‐beta‐hydroxylase estimated in plasma during the clonidine trial are also reported.