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Comparison of peripheral anticholinergic effects of antidepressants: dry mouth
Author(s) -
Rafaelsen O. J.,
Clemmesen L.,
Lund H.,
Mikkelsen P. L.,
Bolwig T. G.
Publication year - 1981
Publication title -
acta psychiatrica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.849
H-Index - 146
eISSN - 1600-0447
pISSN - 0001-690X
DOI - 10.1111/j.1600-0447.1981.tb00741.x
Subject(s) - maprotiline , anticholinergic , clomipramine , mianserin , amitriptyline , imipramine , placebo , nomifensine , medicine , antidepressant , doxepin , anesthesia , dose , nortriptyline , pharmacology , alternative medicine , dopaminergic , pathology , hippocampus , dopamine
Twenty‐one healthy volunteers were given single doses of placebo or antidepressants corresponding to average daily doses of patient medications. Spontaneous whole mouth and parotid salivation was measured two, six, and ten hours after drug administration in session 1; in session 2 after ten hours. The results indicate that a subdivision of antidepressants into four groups can be made according to inhibitory effect on salivation: (a) isocarboxazide and lithium citrate with no effect, (b) zimelidine and nomifensine with slight effect, (c) imipramine oxide and mianserin with moderate effect and (d) maprotiline, nortriptyline, clomipramine, imipramine, and amitriptyline with pronounced effect. Research implications and predictive value for new antidepressants are discussed.