Premium
Reduced expression of erythrocyte complement receptor (C3bR) in MS
Author(s) -
Nowak J.,
Wender M.
Publication year - 1994
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1994.tb01678.x
Subject(s) - phenotype , radioimmunoassay , receptor , complement (music) , complement receptor , medicine , endocrinology , hemagglutination , complement receptor 1 , immunology , complement system , biology , genetics , antibody , gene , complementation
The study was carried out in patients with MS (n‐121) and in control group (n‐519). On the basis of haemagglutination intensity and results of radioimmunoassay three phenotypes of complement receptor were classified: high HH, medium HL, and low LL. Considerable differences were observed in the distribution of these phenotypes between controls and MS in whom the low phenotype was more frequent. Family studies suggest that reduced expression of the complement receptor on the erythrocytes depends in MS on the disease process in the first place, and not on genetic factors.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom