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Immunological abnormalities in the tears of multiple sclerosis patients
Author(s) -
Liedtke W.,
Weller M.,
Wiethölter H.,
Dichgans J.
Publication year - 1992
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1992.tb04034.x
Subject(s) - tears , multiple sclerosis , medicine , immunology , immune system , pathology
IgG and IgM concentrations in tears of multiple sclerosis patients (n = 38) are increased compared to normal controls (n = 23). The occurrence of oligoclonal tear IgG bands (7.9%) — as determined by immunoblotting — did not differ between groups. Our findings suggest an altered reactivity of the secretory immune system in MS patients, but did not differ from findings in patients with eye affections or wearing hard contact lenses.