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Propranolol, clonidine, urapidil and trazodone infusion in essential tremor: a double‐blind crossover trial
Author(s) -
Caccia M. R.,
Osio M.,
Galimberti V.,
Cataldi G.,
Mangoni A.
Publication year - 1989
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1989.tb03804.x
Subject(s) - clonidine , trazodone , anesthesia , placebo , crossover study , medicine , propranolol , psychology , antidepressant , alternative medicine , pathology , hippocampus
ABSTRACT— Accelerometric tremorgrams were recorded from 25 subjects affected by essential tremor and analysed by a Berg‐Fourier frequency analyser before and during venous infusion of the following drugs: propranolol (β‐blocker), clonidine (alpha‐presynaptic adrenergic agonist), urapidil (alpha‐postsynaptic blocker), trazodone (adrenolytic agent) and placebo. The washout interval between infusions was 3 days. Recordings and data analyses were performed in a double‐blind crossover trial. Tremor was classified as: at rest; postural (arms hyperextended); and intention (finger‐nose test). Analysis of the results showed that propranolol and clonidine reduced significantly ( P = 0.01 and P = 0.009, respectively) the power spectrum of postural tremor, but left at rest and intention tremors unchanged. No significant effects on the tremor power spectrum were observed after placebo, urapidil or trazodone administration. None of the drugs had any effect on tremor frequency.