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Quantitation of IgG and albumin in CSF and serum from multiple sclerosis patients by enzyme‐linked immunosorbent assay
Author(s) -
Mehta P. D.,
Mehta S. P.
Publication year - 1987
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1987.tb07906.x
Subject(s) - multiple sclerosis , cerebrospinal fluid , albumin , immunoglobulin g , csf albumin , antibody , medicine , serum albumin , immunology , chemistry
— Immunoglobulin G (IgG) and albumin from unconcentrated cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) and non‐MS controls were quantitated using enzyme‐linked immunosorbent assay (ELISA). The IgG levels, IgG/albumin ratios and IgG indexes were significantly increased in CSF of MS patients compared to those of non‐MS controls. The method is sensitive, rapid and reproducible and can be applied to routine laboratory use for quantitation of IgG and albumin in unconcentrated CSF from humans as well as in experimental animals used as models for demyelinating diseases.