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Indications of the occurrence of inflammatory reactions in the clinical improvement phase in multiple sclerosis patients
Author(s) -
Hammann Klaus P.,
Röder Rolf,
Gies Henriette,
Hopf Hanns Ch.
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb00903.x
Subject(s) - peripheral blood mononuclear cell , multiple sclerosis , prednisone , peripheral , medicine , peripheral blood , immunology , gastroenterology , chemistry , biochemistry , in vitro
– In patients with multiple sclerosis (MS) the spontaneous burst activity (BA) of peripheral blood mononuclear cells was related to the clinical course of the disease. In five patients clinical improvement was found while the BA was significantly increased (more than 300% of the controls). During the appearance of new or deteriorating signs and in the period without clinical changes, the BA was not at all or not markedly increased. In two patients without clinical improvement the BA did not reach levels above 300% of the controls. Our findings suggest that inflammatory reactions represented by the BA occur in the phase of clinical improvement. Since burst‐stimulating activity was found in the serum of MS patients, cytokines produced by activated immuno‐competent cells are assumed to cause the increased BA. A possible role of prednisone and ACTH on the BA of peripheral mononuclear leucocytes is discussed.