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Adrenoleukodystrophy: fatty acid analysis of total glycerophospholipids in erythrocyte membranes
Author(s) -
Antoku Yasunobu,
Sakai Tetsuo,
Goto Ikuo,
Katafuchi Yukihiko,
Sato Hiroshi,
Iwashita Hiroshi,
Kuroiwa Yoshigoro
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb00863.x
Subject(s) - glycerophospholipids , adrenoleukodystrophy , membrane , chromatography , chemistry , fatty acid , erythrocyte membrane , biochemistry , gas chromatography , high performance liquid chromatography , phospholipid , peroxisome , gene
– The saturated fatty acids released from the erythrocyte membranes of four patients with adrenoleukodystrophy (ALD) and 14 diseased controls were analyzed by high performance liquid chromatography. The ratios of C26:0 to other saturated fatty acids in ALD were higher than those of diseased controls, and neither false‐positive nor false‐negative samples were observed. These results suggest that a study of fatty acids of total glycerophospholipids in erythrocyte membranes by high performance liquid chromatography is a useful diagnostic method of ALD.