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Abnormalities of T‐lymphocyte subsets in epileptic patients
Author(s) -
EegOlofsson Orvar,
Prchal Jaroslav F.,
Andermann Frederick
Publication year - 1985
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1985.tb00855.x
Subject(s) - epilepsy , lymphocyte subsets , monoclonal antibody , immunology , lymphocyte , t lymphocyte , medicine , cellular immunity , t cell , antibody , immune system , psychiatry
– This study concerns the distribution of T‐cell subsets as determined by specific monoclonal antibodies in 50 individuals with complex partial seizures (31) and primary generalized tonic‐clonic seizures (19), and in 30 healthy controls. The epileptic group had significantly fewer circulating T4 “helper” lymphocytes and significantly greater number of T8 “suppressor” lymphocytes than the controls. The T4/T8 ratio was consistently significantly lower in the epileptic group. There was no relation between lymphycyte subsets or T4/T8 ratio and antiepileptic medication. The results suggest a derangement of cell‐mediated immunity in individuals with epilepsy.