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Lack of interaction between cimetidine and carbamazepine
Author(s) -
Sonne J.,
Lühdorf K.,
Larsen N. E.,
Andreasen P. B.
Publication year - 1983
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1983.tb04834.x
Subject(s) - cimetidine , carbamazepine , metabolite , drug interaction , pharmacology , medicine , active metabolite , plasma concentration , chemistry , anesthesia , pharmacokinetics , epilepsy , psychiatry
In order to investigate a possible interaction between cimetidine and carbamazepine (CBZ) 7 otherwise healthy epileptic patients on a long‐term monotherapy with CBZ were given cimetidine (1 g daily) for 7 days. No significant alterations in steady‐state plasma concentration of CBZ and the 10,11‐epoxide metabolite (CBZ‐E) were demonstrated.