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Monoclonal gammopathy with neurological signs and symptoms
Author(s) -
Mähönen Markku,
Partanen Juhani,
Collan Yrjö,
Naukkarinen Anita,
Sorvari Tapani,
Sivenius Juhani,
Riekkinen Paavo
Publication year - 1982
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1982.tb04529.x
Subject(s) - polyneuropathy , medicine , biopsy , amyloidosis , pathology , gammopathy , muscle biopsy , monoclonal , antibody , monoclonal antibody , immunology
Clinical, neurophysiological and muscle biopsy findings in ten patients with monoclonal gammopathy are reported. Three patients had polyneuropathy, one had hemiparkinsonism, one migraine and radicular symptoms and one paresthesiae and radicular symptoms. Amyloidosis was not found in muscle biopsy specimens. All but one patient with neurological findings also had positive immunofluorescence staining for tissuebound immunoglobulins in muscle biopsy specimens. The tissue‐bound immunoglobulins usually belonged to the same class as the M‐component. None of the biopsies of patients without neurological findings were positive.