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Influence of disulfiram on the serum concentration of carbamazepine in patients with epilepsy
Author(s) -
Krag Bent,
Dam Mogens,
Angelo Helle,
Christensen Jytte Molin
Publication year - 1981
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1981.tb00794.x
Subject(s) - carbamazepine , disulfiram , phenytoin , drug interaction , metabolite , epilepsy , pharmacology , drug , phenobarbital , medicine , active metabolite , anesthesia , psychiatry
Treatment of alcoholics with phenytoin and disulfiram (DI) simultaneously is complicated and inexpedient because of the marked drug interaction. The aim of this study was to investigate whether an interaction exists between DI and carbamazepine (CBZ). The serum levels of CBZ and the metabolite CBZ‐10, 11‐epoxide were measured by high‐pressure liquid chromatography in seven out‐patients with epilepsy, on monotherapy with CBZ, before and during two weeks administration of DI. Five patients completed the investigation. None were alcoholics. The changes in the serum levels were insignificant, i.e. without clinical importance. Moreover, uncontrolled clinical experience has not indicated any interaction between DI and CBZ. Thus the influence of DI on the metabolism of CBZ is probably negligible. CBZ is suggested, therefore, when anticonvulsive therapy is needed by alcoholics in treatment with DI.