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Deanol and physostigmine in the treatment of L‐dopa‐induced dyskinesias
Author(s) -
Lindeboom S. F.,
Lakke J. P. W. F.
Publication year - 1978
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1978.tb02871.x
Subject(s) - physostigmine , placebo , levodopa , crossover study , medicine , anesthesia , dyskinesia , psychology , pharmacology , parkinson's disease , pathology , alternative medicine , acetylcholine , disease
Deanol and placebo were administered to 10 parkinsonian patients with levodopa‐induced dyskinesias in a double‐blind, crossover fashion. Deanol and placebo did not differ significantly in their effects on dyskinesias. The reported properties of deanol seem to be attributable to a placebo effect. There was no correlation with the results of the physostigmine test. Despite these disappointing results deanol remains intriguing, because in individual cases remarkable improvements on dyskinesias are reported.