Premium
REGIONAL CEREBRAL BLOOD FLOW IN ACUTE EXPERIMENTAL HYPERTENSION
Author(s) -
Johansson Barbor
Publication year - 1974
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1111/j.1600-0404.1974.tb02785.x
Subject(s) - extravasation , vasospasm , blood flow , cerebral blood flow , medicine , autoregulation , anesthesia , ischemia , blood pressure , metaraminol , cats , evans blue , cardiology , subarachnoid hemorrhage , pathology
ABSTRACT 3 H‐ethanol and 125 I‐antipyrine, freely diffusable substances that distribute in brain in proportion to blood flow, were used to indicate regional flow differences in cats with metaraminol‐induced acute hypertension. Areas with blood‐brain barrier dysfunction as indicated with Evans blue or sodium fluorescein extravasation had higher flow than non‐damaged areas suggesting a local failure of autoregulation. The results contradict the theory of vasospasm and ischaemia as the cause of permeability changes in acute hypertension but are consistent with the hypothesis that the vessels are mechanically damaged by the high intraluminal pressure.