Open AccessmiR‐193 expression differentiates telocytes from other stromal cells
Author(s) -
Cismasiu V.B.,
Radu E.,
Popescu L.M.
Publication year - 2011
Publication title -
journal of cellular and molecular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.44
H-Index - 130
eISSN - 1582-4934
pISSN - 1582-1838
DOI - 10.1111/j.1582-4934.2011.01325.x
Subject(s) - stromal cell , microbiology and biotechnology , interstitial cell , microrna , mesenchymal stem cell , interstitial cell of cajal , biology , proto oncogene proteins c kit , intracellular , interstitial space , immunohistochemistry , stem cell , cancer research , immunology , endocrinology , gene , biochemistry , haematopoiesis , stem cell factor
Abstract Telocytes (TCs) are a particular type of interstitial (stromal) cells defined by very long, moniliform telopodes. Their tissue location, between blood vessels and other cells such as cardiomyocytes (CMC) and neurons, suggests a role in intercellular signalling. In order to define a microRNA (miR) signature in cardiac TCs, we have found that miR‐193 is differentially expressed between TCs and other interstitial cells. Because miR‐193 regulates c‐kit, our data support the previous finding that TCs express c‐kit in certain circumstances. In addition, the miRs which are specific to CMC and other muscle cells ( e.g . miR‐133a, miR‐208a) are absent in TCs. Overall the data reinforce the view that TCs are a particular type of interstitial (mesenchymal) cells.