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Mesoporous Calcium Phosphate Via Post‐Treatment of α‐TCP
Author(s) -
Kitamura Makoto,
Ohtsuki Chikara,
Ogata Shinichi,
Kamitakahara Masanobu,
Tanihara Masao,
Miyazaki Toshiki
Publication year - 2005
Publication title -
journal of the american ceramic society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.9
H-Index - 196
eISSN - 1551-2916
pISSN - 0002-7820
DOI - 10.1111/j.1551-2916.2005.00164.x
Subject(s) - mesoporous material , octacalcium phosphate , porosity , chemical engineering , precipitation , phosphate , macropore , materials science , bovine serum albumin , scaffold , adsorption , calcium , specific surface area , chemistry , mineralogy , chromatography , composite material , biomedical engineering , organic chemistry , metallurgy , medicine , physics , meteorology , engineering , catalysis
α‐Tricalcium phosphate (α‐TCP) macroporous ceramic scaffold was chemically treated with a buffered solution at pH=4. Mesopores were formed in the scaffold after the treatment to result in a remarkable increase in surface area of the scaffold. The increase in the surface area is caused by precipitation of octacalcium phosphate (OCP). Bimodal pore size distribution consisting of mesopores and macropores obtained by the treatment of α‐TCP scaffold having higher initial porosity brought about high adsorption of bovine serum albumin (BSA) than monomodal pore size distribution of mesopores. Adsorption of BSA, acidic protein, was suggested to result from crystallographic characters of OCP.