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Microcirculatory Inflammation in Chronic Venous Insufficiency: Current Status and Future Directions
Author(s) -
DURÁN WALTER,
PAPPAS PETER J.,
SCHMIDSCHÖNBEIN GEERT W.
Publication year - 2000
Publication title -
microcirculation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.793
H-Index - 83
eISSN - 1549-8719
pISSN - 1073-9688
DOI - 10.1111/j.1549-8719.2000.tb00151.x
Subject(s) - chronic venous insufficiency , medicine , venous pressure , inflammation , pathogenesis , venous hypertension , intensive care medicine , microcirculation , pathology , cardiology , hemodynamics
One of the hallmarks of chronic venous insufficiency (CVI) is an elevated venous pressure. However, no direct link at the cellular and molecular levels between venous hypertension and actual tissue damage in CVI has been established. Evidence for generation of an inflammatory reaction and several molecular alterations in the development of CVI is discussed. Development of experimental models of CVI, analysis of the mechanical tissue stresses in addition to venous hypertension, in combination with systematic studies of clinically stratified and standardized patient‐derived samples is required for molecular description of the pathogenesis of CVI.