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Potentially Fatal Interaction Between Azithromycin and Disopyramide
Author(s) -
GRANOWITZ ERIC V.,
TABOR KENNETH J.,
KIRCHHOFFER JAMES B.
Publication year - 2000
Publication title -
pacing and clinical electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.686
H-Index - 101
eISSN - 1540-8159
pISSN - 0147-8389
DOI - 10.1111/j.1540-8159.2000.tb00976.x
Subject(s) - disopyramide , medicine , azithromycin , molsidomine , toxicity , pharmacology , antibiotics , microbiology and biotechnology , nitric oxide , biology
A patient on disopyramide developed disopyramide toxicity when treated concurrently with azithromycin. Evidence of toxicity included an elevated serum disopyramide level and ventricular tachycardia requiring cardioversion. The azalide antibiotic presumably inhibited dealkylation of disopyramide to its major metabolite, mono‐N‐dealkyldisopyramide. Physicians should avoid using azithromycin in patients on disopvramide. If this drug combination is unavoidable, disopyramide levels must be closely monitored.