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Measurement of Erythrocyte Survival during Open‐heart Surgery
Author(s) -
Szymanski I. O.,
Dean H. M.,
Valeri C. R.,
Bougas J. A.,
Desforges J. F.
Publication year - 1970
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1970.tb00726.x
Subject(s) - agglutination (biology) , extracorporeal circulation , population , medicine , red blood cell , significant difference , andrology , surgery , immunology , antibody , environmental health
A method of estimating erythrocyte survival during open‐heart surgery is presented. Two erythrocyte populations were transfused simultaneously into the extracorporeal circulation and were compared by measuring the survival of one population with 51 Cr labeling and the other by automated differential agglutination. The difference between the percentage survivals of two erythrocyte populations was calculated. When the survival of a single erythrocyte population was measured simultaneously by chromium labeling and by automated differential agglutination, evidence for elution of chromium from the labeled red blood cells during the operative procedure was not found. A significant increase in the rate of erythrocyte destruction occurred following transfusion of red blood cells that had been stored at 4 C for longer than one week. The destroyed red blood cells apparently represented those irreversibly damaged during storage at 4 C.