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SCREENING OF PHOTOSYNTHETIC O 2 ‐EVOLVING PROKARYOTES FOR AN INSULIN‐LIKE ANTIGEN 1
Author(s) -
Khursheed Saima,
Anwer Razique,
Zutshi Sunaina,
Fatma Tasneem
Publication year - 2012
Publication title -
journal of phycology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.85
H-Index - 127
eISSN - 1529-8817
pISSN - 0022-3646
DOI - 10.1111/j.1529-8817.2011.01086.x
Subject(s) - biology , insulin , spirulina (dietary supplement) , diabetes mellitus , antigen , antibody , biomass (ecology) , endocrinology , medicine , immunology , ecology , raw material
Diabetes mellitus (DM), a metabolic disorder, is becoming a major health problem worldwide. Insulin is the single hope for management of type 1 diabetes, but it is not always available or suitable. For finding additional bioresources, the present study was performed. ELISA‐based preliminary screening of cyanobacterial biomass using antihuman insulin antibody have detected an insulin‐like antigen in Spirulina platensis S‐5, Spirulina NCCU ‐ 482, and Spirulina NCCU ‐ 483. Their similarity with insulin‐like antigen was further confirmed by electrophoretic mobility using bovine insulin as marker.