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Finding a better drug for epilepsy: Antiinflammatory targets
Author(s) -
Dedeurwaerdere Stefanie,
Friedman Alon,
Fabene Paolo F.,
Mazarati Andrèy,
Murashima Yoshiya L.,
Vezzani Annamaria,
Baram Tallie Z.
Publication year - 2012
Publication title -
epilepsia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.687
H-Index - 191
eISSN - 1528-1167
pISSN - 0013-9580
DOI - 10.1111/j.1528-1167.2012.03520.x
Subject(s) - epilepsy , neuroscience , psychology , mechanism (biology) , cognitive science , medicine , epistemology , philosophy
Summary This monograph summarizes one of the sessions of the XI Workshop on Neurobiology of Epilepsy (WONOEP), and provides a critical review of the current state of the field. Speakers and discussants focused on several broad topics: (1) the coexistence of inflammatory processes encompassing several distinct signal‐transduction pathways with the epileptogenic process; (2) evidence for the contribution of specific inflammatory molecules and processes to the onset and progression of epilepsy, as well as to epilepsy‐related morbidities including depression; (3) the complexity and intricate cross‐talk of the pathways involved in inflammation, and the discrete, often opposite roles of a given mediator in neurons versus other cell types. These complexities highlight the challenges confronting the field as it aims to define inflammatory molecules as promising targets for epilepsy prevention and treatment.