Fast Spin‐Echo, Magnetic Resonance Imaging‐Measured Hippocampal Volume: Correlation with Neuronal Density in Anterior Temporal Lobectomy Patients | Zendy

Lee Namsoo | Zendy; Tien Robert D. | Zendy; Lewis Darrell V. | Zendy; Friedman Allan H. | Zendy; Felsberg Gary J. | Zendy; Crain Barbara | Zendy; Hulette Christine | Zendy; Osumi Alan K. | Zendy; Smith Jean S. | Zendy; VanLandingham Kevan E. | Zendy; Radtke Rodney A. | Zendy

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Fast Spin‐Echo, Magnetic Resonance Imaging‐Measured Hippocampal Volume: Correlation with Neuronal Density in Anterior Temporal Lobectomy Patients

Author(s) -

Lee Namsoo,

Tien Robert D.,

Lewis Darrell V.,

Friedman Allan H.,

Felsberg Gary J.,

Crain Barbara,

Hulette Christine,

Osumi Alan K.,

Smith Jean S.,

VanLandingham Kevan E.,

Radtke Rodney A.

Publication year - 1995

Publication title -

epilepsia

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.687

H-Index - 191

eISSN - 1528-1167

pISSN - 0013-9580

DOI - 10.1111/j.1528-1157.1995.tb01633.x

Subject(s) - hippocampal formation , magnetic resonance imaging , temporal lobe , hippocampal sclerosis , anterior temporal lobectomy , atrophy , epilepsy , medicine , nuclear medicine , radiology , pathology , psychiatry

Summary: To assess the value of magnetic resonance imaging (MRI)‐measured hippocampal volume in the detection of hippocampal sclerosis, we studied 28 patients undergoing anterior temporal lobectomy for medically intractable mesial temporal lobe epilepsy. Hippocampal volumetry and visual analysis of T2 signal change were performed using fast spin‐echo T2‐weighted MRI. Quantitative neuronal density measurements were performed in the resected hippocampal specimens. There was a significant correlation between MRI‐measured absolute hippocampal volume (AHV) and neuronal density in CA1, CA2, and CA3 subfields (p<0. 0001, p < 0.01, and p < 0.05, respectively). Differential hippocampal volume (side‐to‐side volume difference) failed to detect bilateral atrophy in three patients, but the bilateral hippocampal atrophy was recognized by considering AHV in these patients. This study suggests that MRI‐measured AHV can be of value in evaluating patients with mesial temporal lobe epilepsy, especially when there is no side‐to‐side difference in hippocampal volumetry.

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