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Bending the Rule of Monotherapy for Migraine Prevention?
Author(s) -
Evans Randolph W.,
Pascual Julio,
Láinez Miguel J.A.,
Leira Rogelio
Publication year - 2005
Publication title -
headache: the journal of head and face pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.14
H-Index - 119
eISSN - 1526-4610
pISSN - 0017-8748
DOI - 10.1111/j.1526-4610.2005.05142.x
Subject(s) - citation , psychology , humanities , library science , philosophy , computer science
CLINICAL HISTORY A 32-year-old woman had migraine without aura 8 times per month. After taking propranolol long acting 160 mg daily for 4 months, the frequency was 6 times monthly. She had previously been on monotherapy with therapeutic doses of amitriptyline, topiramate, and extended release divalproex sodium without benefit. Questions.—Would the patient benefit from the addition of a second preventive medication? What is the evidence for combined therapy for migraine prevention?