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Thrombolysis for Suspected Intrapump Thrombosis in Patients With Continuous Flow Centrifugal Left Ventricular Assist Device
Author(s) -
Muthiah Kavitha,
Robson Desiree,
Macdonald Peter S.,
Keogh Anne M.,
Kotlyar Eugene,
Granger Emily,
Dhital Kumud,
Spratt Phillip,
Jansz Paul,
Hayward Christopher S.
Publication year - 2013
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2012.01567.x
Subject(s) - medicine , thrombolysis , thrombus , thrombosis , ventricular assist device , cardiology , continuous flow , centrifugal pump , hemodynamics , regimen , impeller , heart failure , myocardial infarction , physics , mechanics , thermodynamics
The current recommended anticoagulation regimen during continuous flow centrifugal left ventricular device support is a combination of antiplatelet therapy as well as oral anticoagulation. Despite this, pump thrombosis occurs in rare situations. We report the risk factors and nonsurgical management and outcomes of five patients implanted with continuous flow centrifugal left ventricular assist devices who displayed clinical, hemodynamic, and laboratory features of intrapump thrombosis. This information may support the use of intravenous thrombolytics for suspected pump thrombus in these newer generation devices.