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Echocardiographic Assessment of Global Ventricular Function Using the Myocardial Performance Index in Rats with Hypertrophy
Author(s) -
Salemi Vera M.C.,
Pires Mara D.,
Cestari Ismar N.,
Cestari Idágene A.,
Picard Michael H.,
Leirner Adolfo A.,
Mady Charles
Publication year - 2004
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.2004.47350.x
Subject(s) - cardiology , myocardial hypertrophy , pressure overload , medicine , constriction , ascending aorta , muscle hypertrophy , aorta , left ventricular hypertrophy , doppler echocardiography , cardiac hypertrophy , blood pressure , diastole
Abstract: Myocardial hypertrophy is the hallmark of chronic pressure overload and the myocardial performance index (MPI) is an easily recordable measurement of Doppler time intervals. In this study, the utility of using MPI to assess the progression of hypertrophy in the aortic‐banded rat model was evaluated. Male Wistar rats (70–90 g) underwent ascending aorta constriction ( n = 4) or a sham operation ( n = 5). High‐resolution echocardiography was performed 4, 7, 10, and 12 weeks after the surgery. Over this follow‐up interval, animals in the aortic‐banded group demonstrated an increase in their mean left ventricular (LV) mass and MPI compared with controls. MPI reflects ventricular performance in small animals with LV hypertrophy, showing alterations early after aorta constriction.