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Digoxin Removal from a Patient with Renal Failure by Hemoperfusion with Amberlite XAD‐4 Resin
Author(s) -
Hoy Wendy,
Gibson Thomas P.,
Biddle Theodore
Publication year - 1979
Publication title -
artificial organs
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.684
H-Index - 76
eISSN - 1525-1594
pISSN - 0160-564X
DOI - 10.1111/j.1525-1594.1979.tb01023.x
Subject(s) - hemoperfusion , digoxin , amberlite , medicine , dialysis , peritoneal dialysis , anesthesia , heart failure , chemistry , hemodialysis , organic chemistry , adsorption
ABSTRACT A digitoxic patient with severe renal failure underwent two hemoperfusion treatments with Amberlite XAD‐4 resin. Digoxin clearances calculated from plasma flow rates and plasma digoxin concentrations, as well as from the amount of digoxin eluted from the used columns, were superior to those previously described for peritoneal dialysis, hemodialy‐sis and charcoal hemoperfusion. There was a temporary improvement in the patient's life‐threatening digitoxic cardiac rhythm with the first hemoperfusion, and a permanent improvement after the second hemoperfusion. It is submitted that hemoperfusion with this resin may significantly lessen manifestations of digoxin poisoning and may hasten digoxin elimination in digitoxic patients with renal failure.