Open AccessLipid Profile Correlates With Glycemic Control in Young Patients With Type 1 Diabetes Mellitus
Author(s) -
Ladeia Ana Marice,
Adan Luis,
CoutoSilva Ana Claudia,
Hiltner Ângela,
Guimarães Armênio C.
Publication year - 2006
Publication title -
preventive cardiology
Language(s) - English
Resource type - Journals
eISSN - 1751-7141
pISSN - 1520-037X
DOI - 10.1111/j.1520-037x.2006.4019.x
Subject(s) - medicine , glycemic , dyslipidemia , endocrinology , microalbuminuria , diabetes mellitus , body mass index , creatinine , lipid profile , type 2 diabetes
Data on dyslipidemia in type 1 diabetes is scarce. The authors aimed to evaluate the lipid profile in patients with type 1 diabetes and its correlation to glycemic control. Ninety‐four subjects (53.2% males), aged 15.4±4.7 (3.6–21.9 years), with disease duration of 5.0±3.6 years (0.3–17 years) were evaluated for heart rate, blood pressure, height, and weight. Laboratory data included total cholesterol (TC), high‐density lipoprotein (HDL), low‐density lipoprotein (LDL), triglycerides (TGs), glycemia, glycosylated hemoglobin (HbA 1c ), creatinine, thyroid‐stimulating hormone, antithyroid antibodies, and 24‐hour microalbuminuria. Correlations were performed by the Spearman rank correlation test, and the significance level was <0.05. Mean values were TC, 168.6±46.6 mg/d; HDL, 43.1±15.3 mg/dL; LDL, 110.9±40.6 mg/dL; TGs, 78.3±48.6 mg/dL; glycemia, 204.6±116.7 mg/dL; and HbA 1c , 11.2%±2.9%. High TC (43.9% vs. 10.7%; p <0.002) and LDL (51.5% vs. 10.7%; p <0.01) were more prevalent in patients 19 years and younger (n=66). HbA 1c correlated with TC (r= 0.30; p= 0.004), LDL (r= 0.28; p= 0.008), TG (r= 0.31; p= 0.003), and TG/HDL ratio (r= 0.25; p= 0.01). Duration of diabetes correlated with LDL (r= 0.21; p= 0.04) and insulin daily doses with TG (r= 0.23; p= 0.04) and body mass index expressed as z scores (r= –0.28; p= 0.007). There was a high prevalence of hypercholesterolemia (54.6%) in these diabetic patients, and lipid fraction levels were correlated with HbA 1c . Good management of diabetes seems to be of paramount importance in controlling dyslipidemia.