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Subclinical rhythmic electrographic discharge of adults (SREDA) in a case with spinocerebellar degeneration improved clinically by thyrotropin‐releasing hormone
Author(s) -
FUKUTA Mayuko,
KIRINO Eiji,
INOUE Reiichi,
ARAI Heii
Publication year - 2009
Publication title -
psychogeriatrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.647
H-Index - 32
eISSN - 1479-8301
pISSN - 1346-3500
DOI - 10.1111/j.1479-8301.2008.00260.x
Subject(s) - subclinical infection , thyrotropin releasing hormone , delirium , hormone , medicine , antidiuretic , degeneration (medical) , rhythm , endocrinology , anesthesia , pathology , intensive care medicine
Abstract Herein, we report on a patient with spinocerebellar degeneration who exhibited subclinical rhythmic electrographic discharge of adults (SREDA). Thyrotropin‐releasing hormone (TRH) improved the clinical symptoms and SREDA was observed only when administration of thyrotropin‐releasing hormone was discontinued and the symptoms worsened. Furthermore, after resuming administration of taltirelin hydrate, a TRH analog, the improvement in motor function was accompanied by a decrease in delirium. It is plausible that taltirelin hydrate improved the distorted cerebral blood flow, which has been reported previously as the mechanism underlying SREDA, as a consequence of the functional improvement in neurotransmitter systems.