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Myocardial oxidative stress contributes to transgenic β 2 ‐adrenoceptor activation‐induced cardiomyopathy and heart failure
Author(s) -
Xu Q,
Dalic A,
Fang L,
Kiriazis H,
Ritchie RH,
Sim K,
Gao XM,
Drummond G,
Sarwar M,
Zhang YY,
Dart AM,
Du XJ
Publication year - 2011
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2010.01043.x
Subject(s) - heart failure , cardiomyopathy , oxidative stress , medicine , adrenergic receptor , oxidative phosphorylation , transgene , cardiology , endocrinology , chemistry , receptor , biochemistry , gene
While maintaining cardiac performance, chronic β-adrenoceptor activation eventually exacerbates the progression of cardiac remodelling and failure. We examined the adverse signalling pathways mediated by nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and reactive oxygen species (ROS) after chronic β₂-adrenoceptor activation.