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Advances in imaging of new targets for pharmacological intervention in stroke: real‐time tracking of T‐cells in the ischaemic brain
Author(s) -
Ortolano F,
Maffia P,
Dever G,
Rodolico G,
Millington OR,
De Simoni MG,
Brewer JM,
Bushell TJ,
Garside P,
Carswell HV
Publication year - 2010
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00527.x
Subject(s) - medicine , isoflurane , stroke (engine) , immune system , middle cerebral artery , ex vivo , pathology , brain ischemia , anesthesia , ischemia , in vivo , cardiology , biology , immunology , mechanical engineering , microbiology and biotechnology , engineering
T-cells may play a role in the evolution of ischaemic damage and repair, but the ability to image these cells in the living brain after a stroke has been limited. We aim to extend the technique of real-time in situ brain imaging of T-cells, previously shown in models of immunological diseases, to models of experimental stroke.