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Vitamin D inhibits growth of human airway smooth muscle cells through growth factor‐induced phosphorylation of retinoblastoma protein and checkpoint kinase 1
Author(s) -
Damera G,
Fogle HW,
Lim P,
Goncharova EA,
Zhao H,
Banerjee A,
Tliba O,
Krymskaya VP,
Panettieri, Jr RA
Publication year - 2009
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.2009.00428.x
Subject(s) - calcitriol , platelet derived growth factor receptor , calcitriol receptor , cell growth , endocrinology , growth factor , cell cycle , biology , kinase , medicine , cancer research , microbiology and biotechnology , chemistry , cell , vitamin d and neurology , biochemistry , receptor
Airway remodelling in asthma is manifested, in part, as increased airway smooth muscle (ASM) mass, reflecting myocyte proliferation. We hypothesized that calcitriol, a secosteroidal vitamin D receptor (VDR) modulator, would inhibit growth factor-induced myocyte proliferation.
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