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Pretreatment with rh‐GMCSF, but not rh‐IL3, enhances PAF‐induced eosinophil accumulation in guinea‐pig airways
Author(s) -
Sanjar S.,
Smith D.,
Kings M.A.,
Morley J.
Publication year - 1990
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1990.tb15817.x
Subject(s) - eosinophil , guinea pig , platelet activating factor , granulocyte macrophage colony stimulating factor , immunology , granulocyte , platelet , eosinophil cationic protein , biology , endocrinology , chemistry , medicine , pharmacology , cytokine , asthma
Intraperitoneal injections of recombinant human granulocyte‐macrophage colony stimulating factor (rh‐GMCSF, 50 μg kg −1 daily) or interleukin‐3 (rh‐IL3, 50 μg kg −1 daily) for two days, induced an increase in the percentage of bone marrow and pulmonary airway eosinophils in the guinea‐pig. In addition, rh‐IL3‐treated animals exhibited an increase (21%) in blood neutrophils. Exposure of guinea‐pigs to an aerosol of platelet activating factor (PAF) gives rise to a selective pulmonary eosinophil accumulation, maximal at 48 h. The eosinophilic response to PAF was significantly enhanced in rh‐GMCSF‐treated guinea‐pigs but was suppressed in rh‐IL3‐treated animals.