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Antagonism of N‐methylaspartate and synaptic responses of neurones in the rat ventrobasal thalamus by ketamine and MK‐801
Author(s) -
Salt T.E.,
Wilson D.G.,
Prasad S.K.
Publication year - 1988
Publication title -
british journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.432
H-Index - 211
eISSN - 1476-5381
pISSN - 0007-1188
DOI - 10.1111/j.1476-5381.1988.tb11546.x
Subject(s) - neuroscience , thalamus , chemistry , receptive field , biology
1 Extracellular single neurone recordings were made in the ventrobasal thalamus of urethaneanaesthetized rats. 2 Iontophoretically and intravenously administered ketamine and MK‐801 were found to be selective antagonists of responses of neurones to iontophoretically applied N‐methylaspartate. 3 Both antagonists, administered in N‐methylaspartate‐selective quantities, reduced the synaptic responses of ventrobasal thalamus neurones to a two‐second air jet directed at the peripheral receptive field.